The primary uses of the phosphodiesterase-5 inhibitor Malegra 100 mg tablet are the treatment of pulmonary hypertension and erectile dysfunction.
The enzyme cyclic guanosine monophosphate type 5 phosphodiesterase, which causes the relaxation of pulmonary vascular smooth muscle cells, is specifically and potently inhibited by sildenafil in the corpus cavernosum. By increasing blood flow to the penis, it restores diminished erectile function; however, in order for Sildenafil to have its intended pharmacological benefits, sexual excitement is also necessary.